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Post Uploaded Date : May 23, 2024 Last Updated Date : June 5, 2024
SKU: VEDI25 Availability: In Stock Estimated Delivery : 15-20 Days

Active Compound : Tapentadol hydrochloride

Brand Name : Aspadol

Manufacturer : Marketed By : Signature Pharmaceuticals Ltd.

Aspadol 100mg

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SKU: VEDI25 Categories: ,
Medicine Overview
Country Of Origin India
Dosage Form Oral Tablets
Therapeutic Class Opioid Pain Medication
Packaging  Blister strips with 10 tablets
Delivery Time US to US- 2-3 days with priority shipping 

Overseas Delivery (Outside USA)- 15-20 days

What Is Aspadol Tablet?

Aspadol 100mg tablet is the brand name of Tapentadol, which is not available in generic form. It is a centrally-acting opioid pain medication with a dual mechanism of action. Aspadol tablet has a faster time of action and works within 30 minutes of administration.  

It is available in two formulations- Immediate-Release (IR) tablets and Extended-Release (ER) tablets that treat both acute and chronic body pain, respectively. 

Aspadol Formulations

The Immediate-release tablets of Aspadol are those with a rapid disintegration formula. Following its administration, it is rapidly released in the body to showcase a potent analgesic effect within the first few hours. 

In contrast, the Extended-Release (ER) tablet is designed to release the active ingredient (Tapentadol Hydrochloride) slowly and gradually over a specific period. This allows the analgesic effect to last for a longer period compared to the Aspadol IR tablets. 

Aspadol 100mg Uses

The Immediate-release (IR) tablets of Tapentadol are used to treat pain associated with 

post-surgical, dental pain, Back pain, knee and hip joint pain, migraine, and regional pain syndrome. 

In comparison, Extended-Release (ER) tablets are recommended for managing pain caused by Fibromyalgia, diabetic neuropathy, and bunionectomy. 

The use of Tapentadol in veterinary species is also clinically recommended by doctors. 

Note– Since Tapentadol (Aspadol) is an opioid pain medication, it has a risk of abuse and dependency and thus must be used under the supervision of a physical. 

Medical Benefits Of Aspadol 100mg Tablets

  • Aspadol has a better safety profile compared to other opioid analgesics and thus has a lower possibility of side effects. 
  • The action of Aspadol IR lasts for 4 to 6 hours, whereas the Extended-Release (ER) tablets work for 12 hours. 
  • It is often prescribed by physicians when other pain medications fail to provide effective relief. 

Mechanism Of Action- How Does Tapentadol (Aspadol) Work?

Tapentadol is the first US FDA-approved medication that combines two mechanisms of action, μ-opioid receptor (MOR) agonism and noradrenaline reuptake inhibition (NRI), in a single molecule. 

The μ-opioid receptor (MOR) agonism helps in reducing the pan signal in the brain, while noradrenaline reuptake inhibition (NRI) enhances the body’s natural pain-inhibiting pathways. 

It further works by binding to the specific brain receptor by alternating the way the body perceives and responds to the pain. 

Aspadol (Tapentadol) Metabolism And Elimination

Aspadol is metabolized in the liver to form Tapentadol-O-Glucuronide, which is its major metabolite. The elimination is done by the kidney and depends on the half-life of Aspadol. 

The half-life of Aspadol (Tapentadol) IR is 3.93 hours and takes 3.93 hours for elimination, whereas the half-life of Aspadol ER is 4.4 to 5.9 hours, thus staying in the system for 1.23 days. 

Dosage Guidelines

The Aspadol 100mg tablet can be taken for all its approved medical conditions. 

The maximum dose of Aspadol 100mg IR is 600 mg per day with a dosage interval of 4 to 6 hours. Meanwhile, the maximum dose of Aspadol 100mg ER is 500 mg per day at intervals of 12 hours. However, the frequency of the medication can vary depending on the severity of the pain. 

Aspadol or Tapentadol can cause sleep-related breathing issues and thus may require dosage adjustments in patients with sleep apnea. 

Note- Any change in the dosage must be done under medical supervision. 

Missed Dose-

Any missed dose of Aspadol 100mg should be taken as soon as you remember. But if it is almost time for your next dose, you can skip the missed dose and continue with your regular scheduled dosing. 

Do not double dose to make up for a missed dose of 100mg of Aspadol.


Taking a higher dose of Aspadol or doubling the dose can result in an overdose. Some of the common symptoms of a Tapentad overdose are sweating, slowed breathing,  extreme drowsiness, blurred vision, muscle weakness, confusion, and clammy skin.

How To Take Aspadol 100mg Tablets?

  • Swallow one tablet at a time with water. 
  • Do not break, crush, or chew the tablet, as it can change the effectiveness of the medication. 
  •  It can be taken before or after a meal; however, to avoid nausea, it is best to take Aspadol with food. 
  • Do not abruptly discontinue the intake of Aspadol 100 mg tablets, as it can result in withdrawal symptoms such as anxiety, insomnia, hallucinations, upper respiratory symptoms, tremors, and diarrhea.  It is advisable to follow the tapering method that allows the body to adjust to the lower dose of the medication by gradually decreasing the dosage of the medication. 

Common Side Effects Of This Medicine

The common side effects that can arise from starting the treatment with the Aspadol tablet are listed below. 

  • Stomach pain
  • Vomiting
  • Heartburn
  • Constipation
  • Dry mouth
  • Muscle stiffness
  • Abnormal dream

In rare cases, Aspadol can cause a serious allergic reaction called anaphylaxis, which can be life-threatening if not treated at the right time. Thus, it is essential to check for signs such as itching, trouble swallowing and breathing, and swelling in your mouth, hands, and face. 

The other adverse effects of Aspadol include Loss of coordination, Hoarseness, lightheadedness, Chills, Swelling of the throat, and overheating of the body. In severe cases, these symptoms should be consulted with a doctor immediately. 

Drug Interactions For Aspadol 100mg Tablets

Before starting with Aspadol treatment, mention all your previous treatments and medications to your doctor, as some of them can have a negative drug interaction with Aspadol.  

Aspadol can interact with 375 drugs and causes major drug interaction with Lyrica (pregabalin), hydrocodone, morphine, tramadol, tizanidine, oxycodone, Valium, Xanax, carisoprodol, and gabapentin. 

It can moderately interact with 190 medications, including acrivastine, formoterol, ganaxolone, ketamine, levetiracetam, midazolam, naloxone, and solriamfetol.

It is thus advisable to maintain a safe dosage gap between medicines and use them at intervals to avoid any reactions.

Storage And Disposal

  • The Aspadol 100mg tablets should be stored away from children’s and pets’ reach. 
  • Keep it in the original package at room temperature (20°C to 25°C (68°F to 77°F) away from moisture and direct sunlight. 
  • While disposing of the tablets, wrap them in paper and flush them down the toilet. 

Special Precautions You Must Consider Before Taking Aspadol 100mg Tablets

  • After the administration of Aspadol, it is important for a physician to monitor your progress within the first 24 to 72 hours. Blood and urine tests may be needed to check for any unwanted effects. 
  • Do not take alcohol right before or after taking Aspadol 100 mg dosage. 
  • Inform your doctor if you have a history of heart, liver, or kidney disorders. 
  • Aspadol is a category C pregnancy drug; thus, pregnant women shouldn’t take this medication without consulting a doctor. 
  • Avoid taking Aspadol tablets if you have used MAO inhibitors such as isocarboxazid, methylene blue injection,  linezolid, and phenelzine in the last 14 days. 
  • Its use can decrease the fertility rate in men. 
  • Aspadol use can cause drowsiness, thus making it unsafe to drive or use heavy machinery. 
  • Using Aspadol 100 mg tablets for the long term can cause serious constipation and thus can be prevented by using laxatives and increasing the amount of fiber in your diet. 
  • For Nursing or breastfeeding Mothers-
    • Should be taken only under medical supervision. 
    • After taking the medication, the baby should not be fed for 2 to 3 hours. 
    • Ensure that your baby does not show signs of excessive or increased sleepiness, breathing problems, or limpness.

Aspadol 100mg Price In USA And Discounts-

Vedi Care Health pharmacy is able to retail affordable and genuine Aspadol 100 mg tablets by directly sourcing the medication from the manufacturer (Signature Pharmaceuticals). It is priced at $2.7 per pill for a pill package of 180 tablets. 

The original Cost In the USA Aspadol Price At Vedi Care.  Available discount at Vedi Care 
is $1,745.14 for 100 pills

($17.45 per unit). 

Source- Drugs Website

$500 for 180 pills. 

($2.7 per pill)

Save up to $14.7the 5 per pill by choosing Vedi Care Health to order 100 mg of Aspadol tablets. 

Vedic Care Pharmacy provides additional loyalty benefits to all returning customers by offering free pills on all reorders.


How do you get Aspadol 100 mg discounts at Vedi Care Pharmacy?

Customers with coupon codes can apply them during checkout to avail of their discount.

What is the cost of Aspadol 100 mg tablets?

The cost of 100 mg of Aspadol tablets at Vedi Care Health is $1.52 per pill for a pill package of 200 tablets.

Will I get a refund if I receive a wrong or damaged product?

In case you receive a wrong or damaged product, you can send us a picture of the package within 24 to 48 at our email ID. Our customer team will contact you to help you return the product and get a full refund.

Is COD available at Vedi Care?

No, currently, COD is not available at Vedi Care.

How will I know the status of my order?

After the product is shipped, you will receive a tracking order that will help you know the status of your order. Protection Status
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