Tapentadol

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Drug class  Opioid pain medication 
Tapentadol schedule US – Schedule II

UN – unscheduled

EU – Rx only

AU – S8 (controlled drug)

Routes of administration By mouth 
Excretion  Feces and urine

What Is Tapentadol?

Tapentadol is an opioid pain medication that treats chronic or severe pain. It is prescribed when other medicines of the same class have not worked properly or are not well tolerated. 

This pain medication was approved for use in the United States in 2008. 

Tapentadol Brand Names

Tapentadol hydrochloride is sold under various brand names, such as the following – 

  • Aspadol
  • Tapaday
  • Topcynta
  • Nucynta
  • Palexia 
  • Tydol. 

Tapentadol – Mechanism Of Action

Tapentadol hydrochloride is a single-molecule compound that provides pain relief in two different ways. The dual mode of action of Tapentadol differentiates it from other pain medications. 

Mu-opioid Receptor Agonist Activity 

It helps to eliminate body pain signals by binding to mu-opioid receptors present in the brain. 

Obstruction Of Noradrenaline Re-Uptake

Tapentadol obstructs the reuptake of Noradrenaline, a brain neurotransmitter or chemical messenger that enhances the natural pain-inhibiting pathway. 

Tapentadol Ingredients

Active compound –

  • Tapentadol Hydrochloride

Inactive ingredients –

  • Magnesium stearate
  • Titanium dioxide
  • Polyethylene glycol
  • Titanium dioxide
  • Talc
  • Aluminum oxide
  • Povidone
  • Cellulose
  • Microcrystalline
  • Croscarmellose sodium
  • Polyvinyl alcohol. 

Types Of Tapentadol Formulations 

Tapentadol tablets are available in two formulations – immediate-release(works quickly, as suggested by the name)  and extended-release (the active compound of this type of formulation is released gradually over a specific duration).

The immediate-release Tapentadol pills are designed to provide relief from pain for a short duration, usually 4-6 hours, whereas the extended-release Tapentadol pills are designed to provide relief for a longer duration, usually 8-12 hours. 

What Are The Uses And Benefits Of Tapentadol?

  • Tapentadol provides relief from chronic pain.
  • It is used for postoperative pain management
  • This opioid pain medication treats moderate to severe pain caused by fibromyalgia, arthritis, and diabetic neuropathy. 

Benefits Of Tapentadol 

  • Tapentadol effectively provides pain relief after its administration.
  • It starts showing its effects within half an hour of intake.
  • Tapentadol has a better safety profile compared to other medications of the same class.
  • Most of the side effects of this medication are usually mild.
  • It is available under various brand names, and most of its brands are inexpensive. 

Tapentadol Dosage Strengths 

The immediate-release Tapentadol tablets have dosage strengths of 50 mg, 75 mg, and 100 mg.

The extended-release Tapentadol pills are available in the following dosage strengths – 50 mg, 100 mg, 150 mg, 200 mg, and 250 mg. 

Tapentadol Overdose

Tapentadol can effectively relieve pain when used as directed. An Overdose of this drug, accidentally or intentionally, can be dangerous.

7 signs and symptoms of Tapentadol overdose include – 

  • Blurred vision
  • Confusion
  • Slow breathing
  • Sweating 
  • Clammy skin
  • Muscle weakness
  • Extreme drowsiness.

Tapentadol Withdrawal

Stopping the intake of Tapentadol suddenly without consulting a doctor can produce unwanted withdrawal symptoms. 

Common withdrawal symptoms of Tapentadol are sweating, insomnia, pain, rigors, nausea, tremors, diarrhea, upper respiratory symptoms, anxiety, piloerection (goose bumps), and hallucinations. 

A Comparison Between Tapentadol Brands Available At Vedi Care Health 

Aspadol 

Aspadol is a common brand name manufactured by Signature Pharmaceuticals Limited

At Vedi Care, this brand version of Tapentadol is available in two dosage strengths – Aspadol 100 mg and Aspadol ER 200 mg. Aspadol 100 mg is indicated for short-term relief from moderate to severe acute pain and is most commonly used for neuropathic pain.  Every 4 to 6 hours or as otherwise prescribed by a doctor, take this dosage strength. 

Aspadol ER 200 mg is used for chronic pain management and is taken once or twice a day or as prescribed.  

Aspadol 100 mg costs $1.52 per pill for 200 tablets, whereas Aspadol ER 200 mg at Vedi Care costs $1.17 per pill for a pack of 240 tablets. 

Tapaday

Tapaday, marketed by Kachhela Medex Private Limited, is available in two dosage forms – Tapaday 100 mg and Tapaday 200 mg. 

Tapaday 100 mg is used to relieve moderate to severe pain and is usually advised for patients for quick pain relief without extended effectiveness. 

Tapaday 200 mg, on the other hand, is used for severe pain and is more commonly used for neuropathic pain and is advised for patients who do not respond to lower doses. 

The price of Tapaday 100 mg is $1.12 per pill for 240 tablets, and Tapaday 200 mg is priced at $1.17 per tablet for 240 tablets.

Topcynta

Topcynta, manufactured by Healing Pharma, is another popular brand named Tapentadol.  The available dosage strength of Topcynta at Vedi Care is Topcynta 100 mg.

Topcynta 100 mg is used more commonly for neuropathic pain. The price of Topcynta 100 mg is $1.04 per pill for a pack of 240 pills.

Tap 

Tap contains the active ingredient Tapentadol hydrochloride and is used to provide relief from moderate to severe pain for a short duration. The dosage strength of Tap is available at Vedi Care Health online pharmacy, which is Tap 100 mg. 

Tap 100 mg is also used commonly for neuropathic pain and is taken every 4 to 6 hours. The price of this brand of Tapentadol is $1.03 per pill for 240 pills.

Tapentadol Side Effects

The common side effects of Tapaday 100 mg are as follows – 

  • Dizziness
  • Drowsiness
  • Nausea or vomiting
  • Constipation. 

Serious side effects of this medication include –

  • Seizure
  • Rash
  • Anxiety or hallucinations
  • Fainting
  • Irregular breathing
  • Loss of coordination
  • Severe dizziness, drowsiness, or confusion. 

Long-Term Side Effects Of Tapentadol

The use of this opioid pain medication can also cause long-term side effects like weight loss, anxiety, depression, decreased libido, memory problems, slurred speech, seizures, suicidal thoughts, infertility, low sodium levels, reduced fertility, and impotence. 

Tapentadol Interactions

Tapentadol can interact with 376 drugs, causing 191 moderate, 185 major, and 1 minor interactions.

Major drug interactions Moderate drug interactions 
Alfentanil Atropine
Bupropion Baricitinib
Baclofen Droperidol
Cariprazine Clidinum
Dantrolene Felbamate
Gabapentin Entacapone
Halazepam Ginkgo
Eatazolam Hyoscyamine
Fentanyl Ketamine
Olanzapine Indacaterol
Paliperidone Nabilone
Tasimelteon Melatonin
Zaleplon Vigabatrin
Venlafaxine Salmeterol

The table above does not contain all the possible medications that can interact with Tapentadol. Therefore, always consult your doctor or pharmacist while taking any medication with Tapentadol. 

FAQs

How long does Tapentadol stay in your system?

Tapentadol stays in the system for approximately 20-22 hours.

Is Tapentadol addictive?

If Tapentadol is taken for the long term, it may become habit-forming.

How long does Tapentadol take to work?

Tapentadol begins to show its effect within 30 minutes of intake.

Can you take Tapentadol with paracetamol?

According to the website drugs.com, no interactions were found between Tapentadol and paracetamol.

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