Vardenafil Vs. Sildenafil

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Post Uploaded Date : July 9, 2024 Last Updated Date : July 9, 2024
Vardenafil and Sildenafil are two potent ED medications. They work in the same way as they belong to the same class of drugs known as PDE5 inhibitors.
Both these medications are available in various dosage strengths and brand names.

Erectile dysfunction also known as impotence is a common condition affecting up to 30 million men in the US. Impotence is defined as the inability to get and keep an erection, and it can be caused due to various reasons, such as age and certain medical conditions.

PDE5 inhibitors, also known as phosphodiesterase type 5  inhibitors are a class of drugs commonly used to treat ED in men. Two of the most effective drugs in this class include Vardenafil and Sildenafil.

This blog discusses the key differences and similarities between Sildenafil and Vardenafil. If you’re thinking about taking any of these drugs, you can review this information with your provider. Doing so can help you decide which one of these drugs is right for you.

Sildenafil Vs. Vardenafil – Key Similarities and Differences

The table below outlines some of the similarities and differences between the two medications approved by the FDA (Food and Drug Administration).

Vardenafil Sildenafil
How long does it take to work? 60 minutes after intake. 30 minutes after intake.
How long do the effects last? Up to four hours. Up to four hours.
Dosages available 2.5 mg, 5 mg, 10 mg and 20 mg [1]. 25 mg, 50 mg, and 100 mg.
Usual Dose 5 mg, 10 mg, or 20 mg up to once per day. 25 mg, 50 mg, or 100 mg mg up to once per day.

Sildenafil And Vardenafil Brand Names

Some of the popular brand versions of Sildenafil include – Aurogra 100 mg, Cenforce Professional, Viagra, and Cenforce 100 mg.

Apart from these dosage strengths of the brand versions of Sildenafil, higher dosage strengths of this drug are also available such as Cenforce 150 and 200 mg and Malegra 200 mg.

Vardenafil is also sold under various brand names such as Vitara V 60 mg, Vilitra 20 mg, Vilitra 40 mg, and Levitra.

Are you suffering from ED and looking for the most potent medications to treat this condition? Explore our wide range of ED medication by checking our main category page Erectile Dysfunction Treatment.

How Do Vardenafil And Sildenafil Work?

Vardenafil and Sildenafil work in the same way as both of them are PDE5 inhibitors as mentioned already.

They work by increasing the blood flow to the penis. The increased flow of blood to the penis can lead to an erection.

It is crucial to remember that these medications do not cure ED and they also do not prevent STIs (sexually transmitted infections) or pregnancy [2] [3].

How To Take Vardenafil And Sildenafil?

To get effective results, follow all the instructions on your medication’s label for taking it. Generally, Sildenafil and Vardenafil have similar recommendations for how to consume them, which are as follows:

  • Vardenafil and Sildenafil should be taken about 60 minutes before sexual intercourse for optimal response. However, Sildenafil can be taken anywhere between half an hour and up to four hours before sex.
  • Do not consume more than one tablet in a 24-hour period.
Dosage recommendations for Vardenafil
Starting dose 10 mg
Maximum dose 20 mg
Maximum dosing frequency Once per day
Dosage recommendations for Sildenafil
  • Starting dose
  • 50 mg
  • Maximum dose
  • 100 mg
  • Maximum dosing frequency
  • Once per day

Does Food Affect How These PDE5 Inhibitors Work?

Vardenafil can be affected by high-fat foods. However, changes in food intake are not required based on clinical studies. The prescribing information says that Vardenafil can be administered with or without meals.

On the other hand, Sildenafil can also be consumed with or without food. However, taking this PDE5 inhibitor with a high-fat meal can make the medicine take about an hour longer to show its effects.

Vardenafil And Sildenafil Side Effects

buy Vardenafil
The side effects of Sildenafil and Vardenafil are almost similar and may depend on the dosage of the medication, preexisting medical issues, age, and other factors.

The most common adverse events of Vardenafil and Sildenafil include –

  • Nausea
  • Stuffy nose
  • Indigestion
  • Back pain
  • Headaches
  • Facial flushing [4].

Serious side effects of these medications include –

  • Priapism (prolonged erections that are painful)
  • Sudden vision loss
  • Sudden hearing loss [5].

Note – In the event of any serious side effects after using any one of these PDE5 inhibitors consult your doctor immediately.

Drug Interactions

Vardenafil or Sildenafil interacts with numerous drugs. Be sure to inform your healthcare provider about all the medicines you take, including over-the-counter and prescription drugs, supplements, and vitamins.

Sildenafil or Vardenafil should never be taken with nitrate drugs such as nitroglycerin or isosorbide mononitrate.

Sildenafil or Vardenafil can also interact with other medications, including:

  • Alpha-blockers are used to treat high blood pressure and BPH: examples include Uroxatral (alfuzosin) and Flomax (tamsulosin).
  • Other blood pressure medications include Norvasc (amlodipine).
  • Norvir (ritonavir)
  • Erythromycin
  • Certain antifungals, such as itraconazole and ketoconazole.

Sildenafil Vs. Vardenafil – Which is better?

sildenafil medicine
Few research studies have compared Sildenafil and Vardenafil.

One study by Sheila A. Doggrell published in 2005 compared three erectile dysfunction medications: Sildenafil, Vardenafil, and Tadalafil. In the study, it was found that Vardenafil was stronger than Sildenafil. However, both medications were found to be effective similarly in treating erectile dysfunction.

Another study concluded that both Sildenafil and Vardenafil were well-tolerated, with Vardenafil performing better than Sildenafil [6].

Overall, both drugs are generally effective for treating impotence. The American Urological Association does not recommend any one specific option over another as long as it is appropriate for the individual.

Doctors also recommend other treatment options for ED, such as surgery, making lifestyle changes, and mental health professionals. Lifestyle changes that may help treat ED include exercises and dietary changes.

We have a detailed guide on the best exercises for Erectile dysfunction in men when incorporated with vardenafil or sildenafil, it will help you achieve better results.


Vardenafil and Sildenafil are commonly prescribed medications used to treat impotence. They can help with maintaining and achieving an erection in combination with sexual stimulation.

Both of these medications are part of a class of drugs called PDE5 inhibitors. PDE5 inhibitors work by increasing blood flow to the penis. Because they are in the same drug class, they have many similarities but also some differences.

Overall, there is no “best” medication for impotence since all the medications in this class are generally effective options. Consult your primary healthcare provider for more medical advice on what might work for you.


How long can sildenafil's side effects last?

The side effects of Sildenafil last for a few days to weeks.

Does Cialis lower blood pressure?

Yes. Cialis can slightly lower blood pressure.

How long does Sildenafil last?

The effects of Sildenafil last for four hours.

What is the best drink for erectile dysfunction?

Pomegranate juice, watermelon juice, beet juice, and milk are some of the best drinks for ED.


  1. VARDENAFIL, rxlist
  2. MedlinePlus. Sildenafil. 
  3. MedlinePlus. Vardenafil.
  4. Viagra vs. Levitra: differences and similarities, ro
  5. What to Know About Erectile Dysfunction Drugs, verywellhealth
  6. Comparing vardenafil and sildenafil in the treatment of men with erectile dysfunction and risk factors for cardiovascular disease: a randomized, double-blind, pooled crossover study, NCBI Protection Status
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