Tadalafil

Tadalafil is a medicine you’ve probably not heard of until you are in the position to need it. Millions of men have turned to this medication for help with numerous health conditions. 

In this context, we will summarize what is this medication, what it does, and how to use it safely.

What Is Tadalafil?

Tadalafil is a potent phosphodiesterase type-5 inhibitor that has various therapeutic benefits. This medicine is manufactured by various manufacturers. The use of Tadalafil was approved in the United States in 2003. This drug was initially developed by ICOS Corporation and later it was marketed by Eli Lilly and Company [1].

Tadalafil Brand Name

Below is a table consisting of some of the brand names and manufacturers of Tadalafil. 

Vidalista is available at the following dosage strengths at Vedi Care Health –

• Vidalista Professional (Sublingual tablet)
• Vidalista 20 Mg (Oral tablet)
• Vidalista 40 Mg (Oral tablet)
• Vidalista 60 Mg (Oral tablet). 

Tadalafil Working Mechanism

Tadalafil works by reducing the activity of phosphodiesterase type 5 inhibitors (an enzyme). This enzyme is responsible for breaking down a molecule called cGMP (cyclic guanosine monophosphate) which relaxes the muscles of the body.

By reducing the activity of phosphodiesterase type 5 enzyme, Tadalafil elevates the level of cGMP in the penile area leading to relaxation of muscles in the abdomen, which is important for treating conditions like impotence or ED.

This thus improves blood flow, resulting in a firmer erection. 

For benign prostatic hyperplasia, Tadalafil works by relaxing the smooth muscles in the prostate and bladder and for pulmonary arterial hypertension, this PDE5 inhibitor shows its effects by opening the blood vessels that carry blood to the lungs from the heart, thus allowing easy blood flow. 

Note: It is important to keep in mind that ED pills such as Tadalafil make it easier for you to maintain an erection only when you’re sexually aroused. 

Tadalafil Uses

Tadalafil is approved by the U.S. Food And Drug Administration to treat the following conditions – 

Erectile Dysfunction

Tadalafil is an excellent option for treating Erectile dysfunction. Erectile dysfunction is a condition among men where a man finds it hard to keep and get an erection. 

Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension is a condition that negatively impacts the arteries of the lungs. It is a type of high blood pressure in the pulmonary arteries, which is responsible for carrying oxygen-poor blood to the lungs from your heart. 

Benign Prostatic Hyperplasia

Benign Prostatic Hyperplasia is a common benign tumor found in men. This condition is characterized by a noncancerous enlargement of the prostate gland. 

Tadalafil Benefits

• The effects of this medicine last longer than other medications of the same class. 
• Tadalafil has a very low risk of abuse and addiction.
• The prolonged use of this medicine is generally considered safe.
• Tadalafil has a quick onset of action that is 30 minutes after consumption.
• It is beneficial in increasing the levels of testosterone (a male sex hormone). 

Tadalafil Dosage Regimen

The dosage of Tadalafil varies from condition to condition. Tadalafil is available in dosage strengths of – 2.5 mg, 5 mg, 10 mg, and 20 mg. 

• The dose of Tadalafil for impotence is generally 10 mg. The effects of the pill may last longer than 24 hours, so you should not take the 10 mg or 20 mg dosage. 
• The usual dose of Tadalafil for benign prostatic hyperplasia is 2.5 mg or 5 mg, taken once a day. But, if you are suffering from ED and BPH then the dose is 5 mg. 
• The available dose of Tadalafil for pulmonary arterial hypertension is 20 mg. The usual dose of this medicine for treating this condition is 40 mg – two 20 mg tablets taken once a day [2].

How To Use Tadalafil Appropriately

• Take Tadalafil with a plain glass of water or juice. 
• Individuals can take this medicine on an empty stomach or with food. 
• Do not break or chew the pill.
• Individuals who are taking this ED pill for benign prostatic hyperplasia should make sure to take this medicine at the same time every day. 
• Take Tadalafil as recommended by your doctor. 

Tadalafil Reviews

On the website drugs.com Tadalafil has 754 reviews (81% positive, and 11% negative) and has an average rating of 8.4 out of 10 [3]. 

Tadalafil Warnings

• Avoid food containing vitamin C such as grapefruit while taking Tadalafil. 
• Individuals below the age of 18 should avoid taking Tadalafil.
• The consumption of this medicine among females is not recommended.
• People with kidney dysfunction should avoid taking Tadalafil or consult their doctor for dose adjustments. 
• Before taking Tadalafil make sure that you’re not allergic to any of its composition. 

Tadalafil Interactions

Tadalafil can interact with other medicines too. Therefore, do let your provider know about any medications you’re taking, especially:

• Isosorbide mononitrate
• Isosorbide dinitrate
• Tamsulosin
• Riocoguat
• Rifampin
• Vardenafil
• Erythromycin
• Ketoconazole
• Clarithromycin
• Doxazosin
• Ritonavir
• Itraconazole. 
  

Tadalafil Side Effects

Six common side effects of Tadalafil that are usually mild and do not require medical attention are – 

• Watery eyes
• Sleepiness
• Dry mouth
• Flushing
• Stuffy or runny nose
• Upset stomach.

Three severe side effects of Tadalafil that require medical attention are as follows – 

• Hearing loss
• Vision loss
• Prolonged erection [4].