Does Pregabalin Cause Weight Gain?

It is crucial to understand how medicines impact our bodies, including side effects like weight gain. Pregabalin is a popular medication sold under brand names like Lyrica, Nervigesic, and others. This medication is known as an anticonvulsant and is approved by the FDA to treat conditions like seizures, neuropathic pain associated with spinal cord injury, postherpetic neuralgia, diabetic peripheral neuropathy, and fibromyalgia.

However, as its use among people around the globe has grown, so have concerns about its adverse events. One common concern is weight gain.

So, what’s the link between Pregabalin and weight gain? Let’s find out the answer in this detailed guide.

Does Lyrica Cause Weight Gain?

One of the potential side effects of Pregabalin is weight gain. However, the majority of people won’t gain or will gain only a small amount. The reported incidence of weight gain from Pregabalin ranges from 2% to 14.8% of people.

The following factors may be associated with gaining extra pounds while taking Pregabalin.

Use of other medications 

In a study of patients taking Lyrica for seizures, the mean weight gained was 9 lbs (4 kg) over six months. However, these patients were also taking other medicines for the same class, and weight gain was correlated with high total medicine use [1].

Higher doses and longer periods of use

Weight gain due to Pregabalin may be related to the duration and dose of the medication. A study by Hannah Poppen et al. published in 2021 included patients taking Lyrica for neuropathic pain and found weight gain of 3.6 lbs during 12-18 months. Patients who took higher doses gained more weight: an average of 6.5 lbs.

How Does Pregabalin Cause Weight Gain?

It is not known how Pregabalin causes weight gain. It may increase user’s appetite or make them drowsy, reducing their physical activity. Pregabalin has also been linked with fluid retention, especially in the limbs, which can increase weight [2].

Sometimes, weight gain due to pregabalin may also result from its abuse, but it has not been studied. However, people who abuse Lyrica often take higher doses of the drug than people who are not taking it for clinical reasons, usually three to 20 times the therapeutic dose [3].

This could lead to a higher risk of weight gain, depending on how frequently they are taking Pregabalin for recreational purposes and what other drugs they are using.

Weight gain is seen in a few people taking the medication. Its effectiveness in managing various health ailments outweighs its ability to cause weight gain. So, if you are suffering from neuropathic pain associated with various conditions or seizures, you can check out the popular brand drugs of Pregabalin.

How To Avoid Weight Gain On Pregabalin?

Below are some ways to avoid or reduce weight gain on Pegabalin.

Consult a dietician – Speak to a dietician who can help you come up with a healthy meal plan to satisfy your hunger and control your weight.

Physical workout – Try to perform at least 30 minutes of workout a day. Staying active can also help you reduce the sleepiness Pregabalin can cause.

Eat a balanced diet – If you feel Pregabalin is increasing your appetite, add lean protein (found in poultry, soy, fish, and dried beans) and small amounts of healthy fats to your diet. These foods can keep you feeling fuller for longer because they take longer to digest.

Other Pregabalin Side Effects

Other common side effects of Pregabalin include [4] –

• Increased appetite
• Slurred speech
• Vomiting
• Constipation
• Dry mouth
• Gas and bloating
• Lack of coordination
• Sleepiness
• Fatigue
• Elevated mood
• Headache
• Nausea
• Loss of balance
• Difficulty concentrating
• Fatigue
• Sleepiness.

Conclusion

In conclusion, while Pregabalin can be a potent treatment option for various conditions, its potential to cause weight gain is a concern for some people. It’s crucial for individuals to communicate any changes in their body weight to their doctors and discuss various strategies for weight management.